TCF7 enhances pulmonary hypertension by boosting stressed natural killer cells and their interaction with pulmonary arterial smooth muscle cells

Abstract Background Pulmonary hypertension (PH) is a life-threatening cardio-pulmonary disorder. Whether natural killer (NK) cells could act as participants in PH and the mechanism by which NK cells moderate pulmonary vascular remodeling has not been fully elucidated. Methods Single-cell RNA sequenc...

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Bibliographic Details

Published in:	Respiratory Research
Main Authors:	Li-Wei Wu, Min Chen, Dai-Ji Jiang, Chen-Yu Jiang, Yi-Wei Liu, Bei Feng, Chen-Fei Shi, Xu Huang, Xu Zhang, Xiao-He Xu, Xing-Liang Zhou, Yi Shen, Tian-Yu Liu, Lin-Cai Ye, Yang-Yang He, Hao Zhang, Yi Yan
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Subjects:	Pulmonary hypertension Single cell RNA-seq Natural killer cells TCF7 Pulmonary arterial smooth muscle cells
Online Access:	https://doi.org/10.1186/s12931-025-03276-9