Ovarian cryopreservation with rapamycin improves fertility restoration in a murine orthotopic transplantation model

Abstract Currently, the only fertility preservation option of prepubertal patients is ovarian tissue cryopreservation followed by autotransplantation (OTCTP). Once in remission and patients desire to conceive, autotransplantation of frozen/thawed tissue is performed. A major issue of this technique...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Jules Bindels, Marlyne Squatrito, Laëtitia Bernet, Michelle Nisolle, Carine Munaut
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Subjects:	Ovarian cryopreservation Follicle activation Fertility preservation Rapamycin Ovarian transplantation Animal models
Online Access:	https://doi.org/10.1038/s41598-025-94588-9