Hyaluronic acid/silk fibroin nanoparticles loaded with methotrexate for topical treatment of psoriasis

Systemic administration of methotrexate (MTX), widely regarded as one of the most effective treatments for psoriasis, poses significant challenges due to its high toxicity, limited solubility, and potential for adverse effects. Consequently, developing a topical form of MTX may offer a safer and mor...

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Bibliographic Details

Published in:	International Journal of Pharmaceutics: X
Main Authors:	Lan Cheng, Yanhua Zhang, Qian Xu, Zheng Li, Zulan Liu, Fangyin Dai
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Subjects:	Psoriasis Methotrexate Silk fibroin nanoparticles Hyaluronic acid Inflammatory factor
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590156724000847