Targeting of Mevalonate-Isoprenoid Pathway in Acute Myeloid Leukemia Cells by Bisphosphonate Drugs

Metabolic reprogramming represents a hallmark of tumorigenesis to sustain survival in harsh conditions, rapid growth and metastasis in order to resist to cancer therapies. These metabolic alterations involve glucose metabolism, known as the Warburg effect, increased glutaminolysis and enhanced amino...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Emanuela Chiarella, Clelia Nisticò, Anna Di Vito, Helen Linda Morrone, Maria Mesuraca
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Subjects:	mevalonate pathway AML bisphosphonates small GTPases protein isoprenylation
Online Access:	https://www.mdpi.com/2227-9059/10/5/1146