Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents

RNA viral infections, including those caused by respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Venezuelan Equine encephalitis virus (VEEV), pose a major global health challenge. Here, we report the synthesis and screening of a series of pyrrolo[2...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Belén Martinez-Gualda, Mirthe Graus, Anita Camps, Emiel Vanhulle, Sirle Saul, Siavash Azari, Do Hoang Nhu Tran, Laura Vangeel, Winston Chiu, Johan Neyts, Dominique Schols, Shirit Einav, Kurt Vermeire, Steven De Jonghe
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	7-aza-indole pyrrolo[2,3-b]pyridine respiratory syncytial virus (RSV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Venezuelan equine encephalitis virus (VEEV) adaptor-associated kinase 1
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2022.1058229/full