Effects of Simvastatin on Pharmacokinetics and Anticoagulant Effects of Dabigatran in Healthy Subjects

Higher risk of major hemorrhage associated with concomitant use of dabigatran and simvastatin compared to other statins was previously reported with a suggestion of P-glycoprotein-mediated interaction. The aim of this study was to evaluate the effects of simvastatin on pharmacokinetics and anticoagu...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Hyewon Chung, Jong-Min Kim, Jin-Woo Park, Jihyeon Noh, Kyoung-Ah Kim, Ji-Young Park
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	dabigatran simvastatin interaction pharmacokinetics
Online Access:	https://www.mdpi.com/1424-8247/16/3/364