Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthma

Abstract Mepolizumab (anti-IL5 therapy) reduces asthma exacerbations in urban children with exacerbation-prone eosinophilic asthma. We previously utilized nasal transcriptomics to identify inflammatory pathways (gene co-expression modules) associated with asthma exacerbations despite this therapy. I...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Courtney L. Gaberino, R. Max Segnitz, Kimberly A. Dill-McFarland, Leonard B. Bacharier, Agustin Calatroni, Michelle A. Gill, Jeffrey Stokes, Andrew H. Liu, Robyn T. Cohen, Rajesh Kumar, Abigail Lang, Gurjit K. Khurana Hershey, Michael G. Sherenian, Edward M. Zoratti, Stephen J. Teach, Meyer Kattan, Patrice M. Becker, Alkis Togias, William W. Busse, Daniel J. Jackson, Matthew C. Altman
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-09-01
Online Access:	https://doi.org/10.1038/s41467-025-63629-2