Discovery of New 1,4,6-Trisubstituted-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridines with Anti-Tumor Efficacy in Mouse Model of Breast Cancer

Purine analogues are important therapeutic tools due to their affinity to enzymes or receptors that are involved in critical biological processes. In this study, new 1,4,6-trisubstituted pyrazolo[3,4-<i>b</i>]pyridines were designed and synthesized, and their cytotoxic potential was been...

Full description

Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Maria Georgiou, Nikolaos Lougiakis, Roxane Tenta, Katerina Gioti, Stavroula Baritaki, Lydia-Evangelia Gkaralea, Elisavet Deligianni, Panagiotis Marakos, Nicole Pouli, Dimitris Stellas
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	purine analogues pyrazolopyridine antiproliferative activity anticancer agent in vivo breast cancer
Online Access:	https://www.mdpi.com/1999-4923/15/3/787