Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Abstract The peripheral immune system contributes to the development of sepsis‐induced cardiomyopathy. However, the underlying mechanisms linking central immune cells and neurons to sepsis‐induced cardiomyopathy remain to be clarified. Here, acute sepsis is induced by cecal ligation puncture (CLP),...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu
Format:	Article
Language:	English
Published:	Wiley 2025-10-01
Subjects:	andrenergic receptor alpha‐2 astrocyte GABAergic neurons sepsis‐induced cardiomyopathy spinal
Online Access:	https://doi.org/10.1002/advs.202504406