Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis

Abstract Pseudorabies virus (PRV) causes viral encephalitis, a devastating disease with high mortality worldwide. Curcumin (CUR) can reduce inflammatory damage by altering the phenotype of microglia; however, whether and how these changes mediate resistance to PRV-induced encephalitis is still uncle...

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Bibliographic Details

Published in:	Veterinary Research
Main Authors:	Luqiu Feng, Guodong Luo, Yuhang Li, Chen Zhang, Yuxuan Liu, Yanqing Liu, Hongyue Chen, Daoling He, Yan Zhu, Ling Gan
Format:	Article
Language:	English
Published:	BMC 2023-03-01
Subjects:	BV2 Curcumin PRV phenotype AMPK mitochondria
Online Access:	https://doi.org/10.1186/s13567-023-01149-x