Dimethyl sulfoxide in cryopreserved mesenchymal stromal cell therapy products: is there a safety risk to patients?

Abstract Dimethyl sulfoxide (DMSO) is the preferred cryoprotectant for the cryopreservation of mesenchymal stromal cells (MSCs). As DMSO has been associated with in-vivo toxicity, its potential side effects when administered with MSC therapies are a matter of debate. To contribute to the assessment...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Elke Niebergall-Roth, Mark Andreas Kluth
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Cryopreservation Dimethyl sulfoxide Mesenchymal stromal cells Toxicity Safety
Online Access:	https://doi.org/10.1186/s12967-025-06807-6