Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex
HNRNPU is an RNA splicing protein associated with brain disorders such as early onset seizures. Here they show that HNRNPU functions to maintain neural progenitors and their progeny by regulating splicing of key neuronal genes.
| Published in: | Nature Communications |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Online Access: | https://doi.org/10.1038/s41467-022-31752-z |
| _version_ | 1852738745400295424 |
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| author | Tamar Sapir Aditya Kshirsagar Anna Gorelik Tsviya Olender Ziv Porat Ingrid E. Scheffer David B. Goldstein Orrin Devinsky Orly Reiner |
| author_facet | Tamar Sapir Aditya Kshirsagar Anna Gorelik Tsviya Olender Ziv Porat Ingrid E. Scheffer David B. Goldstein Orrin Devinsky Orly Reiner |
| author_sort | Tamar Sapir |
| collection | DOAJ |
| container_title | Nature Communications |
| description | HNRNPU is an RNA splicing protein associated with brain disorders such as early onset seizures. Here they show that HNRNPU functions to maintain neural progenitors and their progeny by regulating splicing of key neuronal genes. |
| format | Article |
| id | doaj-art-b79fbbfd33ea4996851afbb74dc44821 |
| institution | Directory of Open Access Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| spelling | doaj-art-b79fbbfd33ea4996851afbb74dc448212025-08-19T21:05:40ZengNature PortfolioNature Communications2041-17232022-07-0113111410.1038/s41467-022-31752-zHeterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortexTamar Sapir0Aditya Kshirsagar1Anna Gorelik2Tsviya Olender3Ziv Porat4Ingrid E. Scheffer5David B. Goldstein6Orrin Devinsky7Orly Reiner8Department of Molecular Genetics, Weizmann Institute of ScienceDepartment of Molecular Genetics, Weizmann Institute of ScienceDepartment of Molecular Genetics, Weizmann Institute of ScienceDepartment of Molecular Genetics, Weizmann Institute of ScienceFlow Cytometry Unit, Life Sciences Core Facilities, Weizmann Institute of ScienceThe University of Melbourne, Austin Health and Royal Children’s Hospital, Florey and Murdoch Children’s Research InstitutesInstitute for Genomic Medicine, Columbia UniversityNYU Langone Medical Center, NYUDepartment of Molecular Genetics, Weizmann Institute of ScienceHNRNPU is an RNA splicing protein associated with brain disorders such as early onset seizures. Here they show that HNRNPU functions to maintain neural progenitors and their progeny by regulating splicing of key neuronal genes.https://doi.org/10.1038/s41467-022-31752-z |
| spellingShingle | Tamar Sapir Aditya Kshirsagar Anna Gorelik Tsviya Olender Ziv Porat Ingrid E. Scheffer David B. Goldstein Orrin Devinsky Orly Reiner Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex |
| title | Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex |
| title_full | Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex |
| title_fullStr | Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex |
| title_full_unstemmed | Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex |
| title_short | Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex |
| title_sort | heterogeneous nuclear ribonucleoprotein u hnrnpu safeguards the developing mouse cortex |
| url | https://doi.org/10.1038/s41467-022-31752-z |
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