Contribution of BCR-ABL kinase domain mutations to imatinib mesylate resistance in Philadelphia chromosome positive Malaysian chronic myeloid leukemia patients

Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is mediated by different mechanisms that can be classified as <em>BCR-ABL</em> dependent or <em>BCR-ABL</em> independent pathways. <em>BCR-ABL</em> dependent mechanisms...

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Bibliographic Details

Published in:	Hematology Reports
Main Authors:	Marjanu Hikmah Elias, Abdul Aziz Baba, Azlan Husin, Abu Dzarr Abdullah, Rosline Hassan, Goh Ai Sim, S. Fadilah Abdul Wahid, Ravindran Ankathil
Format:	Article
Language:	English
Published:	MDPI AG 2012-11-01
Subjects:	chronic myeloid leukemia, imatinib mesylate, BCR-ABL dependent mechanisms, tyrosine kinase domain, mutation
Online Access:	http://www.pagepress.org/journals/index.php/hr/article/view/4413