Improvement of loperamide-hydrochloride-induced intestinal motility disturbance by Platycodon grandiflorum polysaccharides through effects on gut microbes and colonic serotonin

Constipation is a common gastrointestinal symptom characterized by intestinal motility disorder. The effects of Platycodon grandiflorum polysaccharides (PGP) on intestinal motility have not been confirmed. We established a rat model of constipation induced by loperamide hydrochloride to elucidate th...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Mengqi Hao, Jing Song, Xiaohu Zhai, Nuo Cheng, Cong Xu, Shuangying Gui, Juan Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Subjects:	platycodon grandiflorum polysaccharide intestinal motility disturbance 5-hydroxytryptamine gut microbiota constipation
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2023.1105272/full