Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Abstract The tumor microenvironment promotes cancer progression in part by supporting cancer stem cells (CSC). In colorectal cancer (CRC), progastrin (PG), an orphan growth factor secreted by tumor cells within the tumor and its microenvironment, maintains CSCs by unidentified mechanisms. Here, the...

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出版年:	Advanced Science
主要な著者:	Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche
フォーマット:	論文
言語:	英語
出版事項:	Wiley 2025-10-01
主題:	cancer stem cells colon cancer mAb receptor signaling targeted therapy
オンライン･アクセス:	https://doi.org/10.1002/advs.202502136