Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions

Summary: C9orf72 repeat expansions are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Poly(GR) proteins are toxic to neurons by forming cytoplasmic inclusions that sequester RNA-binding proteins including stress granule (SG) proteins. However,...

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書誌詳細

出版年:	Cell Reports
主要な著者:	Jinyoung Park, Yanwei Wu, Wei Shao, Tania F. Gendron, Sophie J.F. van der Spek, Grigorii Sultanakhmetov, Avik Basu, Paula Castellanos Otero, Caroline J. Jones, Karen Jansen-West, Lillian M. Daughrity, Sadhna Phanse, Giulia del Rosso, Jimei Tong, Monica Castanedes-Casey, Lulu Jiang, Jenna Libera, Björn Oskarsson, Dennis W. Dickson, David W. Sanders, Clifford P. Brangwynne, Andrew Emili, Benjamin Wolozin, Leonard Petrucelli, Yong-Jie Zhang
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2023-08-01
主題:	CP: Neuroscience CP: Molecular biology
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124723008331