The role of complement C3 deposition in ANCA-associated glomerulonephritis: a registry-based study of clinical, histopathological, and prognostic insights

Abstract Background ANCA-associated glomerulonephritis (ANCA-GN) is a leading cause of pauci-immune crescentic GN. Recent evidence indicates that complement activation, marked by C3 deposition in glomeruli, may contribute to more severe renal injury and influence renal outcomes. We aim to evaluate t...

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Bibliographic Details

Published in:	BMC Nephrology
Main Authors:	Sami Uzun, Ebru Gok Oguz, Abdülmecit Yıldız, Ulver Derici, Emre Cankaya, Gulizar Sahin, Erhan Tatar, Garip Şahin, Mevlüt Tamer Dinçer, Necmi Eren, Kenan Turgutalp, Taner Baştürk, Melike Betül Öğütmen, Mehmet Tanrısev, Sim Kutlay, Murvet Yilmaz, Meltem Gürsu, Zülfükar Yılmaz, Zeki Toprak, Onur Tunca, Şebnem Karakan, Ece Ük, Belda Dursun, Mahmud İslam, Dilek Torun, Cuma Bulent Gul, Bulent Kaya, Bülent Altun, Abdulkadir Çelik, İdris Şahin, Serap Yadigar, Dilek Gibyeli Genek, Mehmet Deniz Ayli, Saide Elif Güllülü Boz, Omer Faruk Akcay, Meryem Keleş, Savaş Öztürk
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	ANCA Complement Glomerulonephritis Complement deposition
Online Access:	https://doi.org/10.1186/s12882-025-04355-1