Astrocyte-neuron combined targeting for CYP46A1 gene therapy in Huntington’s disease

Abstract Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by an abnormal expansion of cytosine-adenine-guanosine (CAG) trinucleotidein the huntingtin gene. Mutant huntingtin (mHTT) expression in neurons and glial cells affects neuron and astrocyte functions and lea...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Louis-Habib Parsai, Farah Chali, Enejda Subashi, Caroline Zeitouny, Emilie Rey, A. Berniard, William Bitton, Laureline Urli, Lisa Rousselot, Nadège Sarrazin, Véronique Blouin, Wilfried F. A. Den Dunnen, Kristin Michaelsen-Preusse, Martin Korte, Sandro Alves, Nathalie Cartier
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Cholesterol Astrocytes Neurons Synapses Inflammation
Online Access:	https://doi.org/10.1186/s40478-025-02054-4