Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans.

In C. elegans, removal of the germline extends lifespan significantly. We demonstrate that the nuclear hormone receptor, NHR-49, enables the response to this physiological change by increasing the expression of genes involved in mitochondrial β-oxidation and fatty-acid desaturation. The coordinated...

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Bibliographic Details

Published in:	PLoS Genetics
Main Authors:	Ramesh Ratnappan, Francis R G Amrit, Shaw-Wen Chen, Hasreet Gill, Kyle Holden, Jordan Ward, Keith R Yamamoto, Carissa P Olsen, Arjumand Ghazi
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-12-01
Online Access:	http://europepmc.org/articles/PMC4256272?pdf=render