Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia

Fibroblasts are versatile cells that play a major role in wound healing by synthesizing and remodeling the extracellular matrix (ECM). In cancers, fibroblasts play an expanded role in tumor progression and dissemination, immunosuppression, and metabolic support of cancer cells. In prostate cancer (P...

Full description

Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Jesus Pacheco-Torres, Raj Kumar Sharma, Yelena Mironchik, Flonne Wildes, W. Nathaniel Brennen, Dmitri Artemov, Balaji Krishnamachary, Zaver M. Bhujwalla
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Subjects:	fibroblast hypoxia metabolism prostate cancer cancer associated fibroblast PD-L1
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2024.1354076/full