FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation

The authors used multi-disciplinary approaches to understand the structural mechanism underlying spontaneous aggregation of tau encoding an S320F FTD-tau mutant. Understanding the mechanisms of tau aggregation will help identify novel methods to regulate its misfolding.

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Dailu Chen, Sofia Bali, Ruhar Singh, Aleksandra Wosztyl, Vishruth Mullapudi, Jaime Vaquer-Alicea, Parvathy Jayan, Shamiram Melhem, Harro Seelaar, John C. van Swieten, Marc I. Diamond, Lukasz A. Joachimiak
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-03-01
Online Access:	https://doi.org/10.1038/s41467-023-37274-6