Increase in wasteosomes (corpora amylacea) in frontotemporal lobar degeneration with specific detection of tau, TDP-43 and FUS pathology

Abstract Wasteosomes (or corpora amylacea) are polyglucosan bodies that appear in the human brain with aging and in some neurodegenerative diseases, and have been suggested to have a potential role in a nervous system cleaning mechanism. Despite previous studies in several neurodegenerative disorder...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Raquel Alsina, Marta Riba, Agnès Pérez-Millan, Sergi Borrego-Écija, Iban Aldecoa, Clara Romera, Mircea Balasa, Anna Antonell, Albert Lladó, Yaroslau Compta, Jaume del Valle, Raquel Sánchez-Valle, Carme Pelegrí, Laura Molina-Porcel, Jordi Vilaplana
Format:	Article
Language:	English
Published:	BMC 2024-06-01
Subjects:	Frontotemporal lobar degeneration (FTLD) Wasteosomes Corpora amylacea Tau TDP-43 FUS
Online Access:	https://doi.org/10.1186/s40478-024-01812-0