Design of immunogens to present a tumor-specific cryptic epitope
Abstract In many cancers, the epidermal growth factor receptor (EGFR) gene is amplified, mutated, or both. The monoclonal antibody mAb806 binds selectively to cancer cells that overexpress EGFR or express the truncated mutant EGFRvIII, but not to normal cells. This suggests that a promising avenue f...
| Published in: | Scientific Reports |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Online Access: | https://doi.org/10.1038/s41598-025-94295-5 |