Randomized phase III trial of adjuvant chemotherapy with S-1 after curative treatment in patients with squamous-cell carcinoma of the head and neck (ACTS-HNC).

BACKGROUND:We conducted a phase III study to evaluate S-1 as compared with UFT as control in patients after curative therapy for stage III, IVA, or IVB squamous-cell carcinoma of the head and neck (SCCHN). PATIENTS AND METHODS:Patients were randomly assigned to the UFT group (300 or 400 mg day-1 for...

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Published in:	PLoS ONE
Main Authors:	Kiyoaki Tsukahara, Akira Kubota, Yasuhisa Hasegawa, Hideki Takemura, Tomonori Terada, Takahide Taguchi, Kunihiko Nagahara, Hiroaki Nakatani, Kunitoshi Yoshino, Yuichiro Higaki, Shigemichi Iwae, Takeshi Beppu, Yutaka Hanamure, Kichinobu Tomita, Naoyuki Kohno, Kazuyoshi Kawabata, Masanori Fukushima, Satoshi Teramukai, Masato Fujii, ACTS-HNC group
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Online Access:	http://europepmc.org/articles/PMC4324826?pdf=render