A VH4-34+ myeloma protein with weak autoreactivity

It has been suggested that VH4-34 gene segment expression is counter-selected in multiple myeloma (MM) due to a self-tolerance mechanism. We cloned and sequenced a VH4-34 gene segment from bone marrow mononuclear cells of a stage III MM patient. We show that VH4-34 was expressed by the serum IgA mye...

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Bibliographic Details
Published in:Haematologica
Main Authors: Marianne Frøyland, Keith M. Thompson, Susan J. Thorpe, Surinder S. Sahota, Tobias Gedde-Dahl, Bjarne Bogen
Format: Article
Language:English
Published: Ferrata Storti Foundation 2007-05-01
Online Access:https://haematologica.org/article/view/4444