The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites

A hallmark of retroviral replication is integration of the viral genome into host cell DNA. This characteristic makes retrovirus-based vectors attractive delivery vehicles for gene therapy. However, adverse events in gene therapeutic trials, caused by activation of proto-oncogenes due to murine leuk...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Jan De Rijck, Christine de Kogel, Jonas Demeulemeester, Sofie Vets, Sara El Ashkar, Nirav Malani, Frederic D. Bushman, Bart Landuyt, Steven J. Husson, Katrien Busschots, Rik Gijsbers, Zeger Debyser
Format:	Article
Language:	English
Published:	Elsevier 2013-11-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124713005639