The collectin SP-A and its trimeric recombinant fragment protect alveolar epithelial cells from the cytotoxic and proinflammatory effects of human cathelicidin in vitro

Human cathelicidin (LL-37) is a defense peptide with antimicrobial activity against various pathogens. However, LL-37 can also trigger tissue injury by binding to host cell membranes. The cytotoxic effects of LL-37 may be especially relevant in chronic respiratory diseases characterized by increased...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Lidia de Tapia, Belén García-Fojeda, Nina Kronqvist, Jan Johansson, Cristina Casals
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	cathelicidin LL-37 collectin SP-A trimeric recombinant fragment antimicrobial activity cytotoxicity inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.994328/full