Isoorientin Ameliorates APAP-Induced Hepatotoxicity via Activation Nrf2 Antioxidative Pathway: The Involvement of AMPK/Akt/GSK3β

Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been shown to have antioxidant potential. However, the effect of Iso on APAP-induced liver injury has not yet been elucidated. Th...

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Bibliographic Details
Published in:Frontiers in Pharmacology
Main Authors: Xiaoye Fan, Hongming Lv, Lidong Wang, Xuming Deng, Xinxin Ci
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Subjects:
acetaminophen APAP
hepatotoxicity
Isoorientin Iso
Nrf2
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01334/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.01334/full

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