Engineered Microparticles for Treatment of Murine Brain Metastasis by Reprograming Tumor Microenvironment and Inhibiting MAPK Pathway

Abstract Brain metastases (BRM) are common in advanced lung cancer. However, their treatment is challenging due to the blood‐brain barrier (BBB) and the immunosuppressive tumor microenvironment (ITME). Microparticles (MPs), a type of extracellular vesicle, can serve as biocompatible drug delivery ve...

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Bibliographic Details
Published in:Advanced Science
Main Authors: Lisen Lu, Huaduan Zi, Jie Zhou, Jing Huang, Zihan Deng, Zijian Tang, Li Li, Xiujuan Shi, Pui‐Chi Lo, Jonathan F. Lovell, Deqiang Deng, Chao Wan, Honglin Jin
Format: Article
Language:English
Published: Wiley 2023-03-01
Subjects:
blood‐brain barrier
cancer immunotherapy
extracellular vesicles
macrophages polarization
USP7
Online Access:https://doi.org/10.1002/advs.202206212

Internet

https://doi.org/10.1002/advs.202206212

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