In the skin lesions of patients with mycosis fungoides, the number of MRGPRX2-expressing cells is increased and correlates with mast cell numbers

BackgroundMycosis fungoides (MF) is an indolent T-cell lymphoma that mainly affects the skin and presents with itch in more than half of the patients. Recently, the expression of Mas-related G protein-coupled receptor X2 (MRGPRX2), a receptor of mast cell (MC) responsible for the IgE-independent non...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Man Hu, Polina Pyatilova, Sabine Altrichter, Caibin Sheng, Nian Liu, Dorothea Terhorst-Molawi, Katharina Lohse, Katharina Ginter, Viktoria Puhl, Marcus Maurer, Martin Metz, Pavel Kolkhir
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	cutaneous T cell lymphoma mycosis fungoides pruritus MRGPRX2 mast cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197821/full