Novel Complex of PD-L1 Aptamer and Holliday Junction Enhances Antitumor Efficacy in Vivo

Blocking the PD-1/PD-L1 pathway can diminish immunosuppression and enhance anticancer immunity. PD-1/PD-L1 blockade can be realized by aptamers, which have good biocompatibility and can be synthesized in quantity economically. For in vivo applications, aptamers need to evade renal clearance and nucl...

Full description

Bibliographic Details

Published in:	Molecules
Main Authors:	Ting Li, Fengjiao Yao, Yacong An, Xundou Li, Jinhong Duan, Xian-Da Yang
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Subjects:	aptamer Holliday Junction immunotherapy
Online Access:	https://www.mdpi.com/1420-3049/26/4/1067