Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons. As with the majority of neurodegenerative diseases, the pathological hallmarks of ALS involve proteinopathies which lead to the formation o...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Bridget C. Benson, Pamela J. Shaw, Mimoun Azzouz, J. Robin Highley, Guillaume M. Hautbergue
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-12-01
Subjects:	proteinopathies RNA metabolism alteration mitochondrial dysfunction impaired proteostasis amyotrophic lateral sclerosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2021.783624/full