Involvement of the tryptophan-kynurenine pathway in the pathogenesis of autoimmune diseases

The kynurenine pathway (KP), a major metabolic pathway for L-tryptophan (Trp) in mammals, plays a multifaceted role in various physiological processes, including neural activity, immune system regulation, and the maintenance of intestinal homeostasis. The functional connection between the KP and imm...

Full description

Bibliographic Details

Published in:	Experimental Gerontology
Main Authors:	A-Yuan Chen, Ying-Jie Zhao, Yue-Ye Wang, Wei Wei, Wei Hu, Yan Chang
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	Autoimmune disease Tryptophan Kynurenine pathway Indoleamine 2,3-dioxygenase Tryptophan 2,3- dioxygenase Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S0531556525001664