Heterogeneity of Cellular Senescence: Cell Type-Specific and Senescence Stimulus-Dependent Epigenetic Alterations

The aim of the present study was to provide a comprehensive characterization of whole genome DNA methylation patterns in replicative and ionizing irradiation- or doxorubicin-induced premature senescence, exhaustively exploring epigenetic modifications in three different human cell types: in somatic...

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Bibliographic Details

Published in:	Cells
Main Authors:	Katarzyna Malgorzata Kwiatkowska, Eleni Mavrogonatou, Adamantia Papadopoulou, Claudia Sala, Luciano Calzari, Davide Gentilini, Maria Giulia Bacalini, Daniele Dall’Olio, Gastone Castellani, Francesco Ravaioli, Claudio Franceschi, Paolo Garagnani, Chiara Pirazzini, Dimitris Kletsas
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	replicative senescence stress-induced premature senescence methylation epigenetics human fibroblasts mesenchymal stem cells
Online Access:	https://www.mdpi.com/2073-4409/12/6/927