Generation of a hTERT-Immortalized Human Sertoli Cell Model to Study Transporter Dynamics at the Blood-Testis Barrier

The blood-testis barrier (BTB) formed by adjacent Sertoli cells (SCs) limits the entry of many chemicals into seminiferous tubules. Differences in rodent and human substrate-transporter selectivity or kinetics can misrepresent conclusions drawn using rodent in vitro models. Therefore, human in vitro...

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出版年:	Pharmaceutics
主要な著者:	Raymond K. Hau, Siennah R. Miller, Stephen H. Wright, Nathan J. Cherrington
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2020-10-01
主題:	cell immortalization sertoli cell blood–testis barrier testes xenobiotic transporter drug disposition
オンライン･アクセス:	https://www.mdpi.com/1999-4923/12/11/1005