Identification of the flotillin-1/2 heterocomplex as a target of autoantibodies in bona fide multiple sclerosis

Abstract Background Autoantibodies, in particular those against aquaporin-4 and myelin-oligodendrocyte glycoprotein (MOG), aid as biomarkers in the differential diagnosis of demyelination. Here, we report on discovery of autoantibodies against flotillin in patients with multiple sclerosis (MS). Meth...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	S. Hahn, G. Trendelenburg, M. Scharf, Y. Denno, S. Brakopp, B. Teegen, C. Probst, K. P. Wandinger, M. Buttmann, A. Haarmann, F. Szabados, M. vom Dahl, T. Kümpfel, P. Eichhorn, H. Gold, F. Paul, S. Jarius, N. Melzer, W. Stöcker, L. Komorowski
Format:	Article
Language:	English
Published:	BMC 2017-06-01
Subjects:	Autoantibodies Flotillin Reggie Histo-immunoprecipitation Multiple sclerosis Optic neuritis
Online Access:	http://link.springer.com/article/10.1186/s12974-017-0900-z