Expression of amyotrophic lateral sclerosis associated protein disulfide isomerase A3 D217N variant recapitulates early morphological alterations at the neuromuscular junction

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by neuromuscular connectivity decline followed by motoneuron loss. Altered proteostasis is suggested as a transversal pathogenic mechanism, notably involving dysfunction at the level of the endoplasmic reticulum (...

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發表在:	Neurobiology of Disease
Main Authors:	Martin Sepulveda, Francisca MartinezTraub, Patricia Ojeda, Jessica Mella, Jorge Ojeda, Cristina Pinto, Rodrigo Diaz, Pablo Rozas, Claudia Sepulveda, Bredford Kerr, Vania Morales, Mirva Saaranen, Lloyd Ruddock, Danilo B. Medinas, Juan Pablo Henriquez, Claudio Hetz
格式:	Article
語言:	英语
出版:	Elsevier 2025-10-01
主題:	Amyotrophic lateral sclerosis Endoplasmic reticulum Protein disulfide isomerase Proteostasis Neuromuscular junction
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S096999612500261X