Targeting LINC01711 in FAP+ cancer-associated fibroblasts overcomes lactate-mediated immunosuppression and enhances anti-PD-1 efficacy in lung adenocarcinoma

Abstract The limited response rate to immune checkpoint inhibitors (ICIs) remains a significant challenge in the treatment of lung adenocarcinoma (LUAD). In our study, we identified a lactate-based chemical barrier surrounding FAP+ cancer-associated fibroblasts (CAFs) within the LUAD microenvironmen...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Qinglin Wang, Yuxiang Sun, Jianyu Li, Zhizong Li, Fangwei Yuan, Zhijun Xia, Fanchen Meng, Ziyang Shen, Yiyang Shen, Lin Xu, Jie Wang, Xi Chen, Tongyan Liu, Rong Yin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-08-01
Online Access:	https://doi.org/10.1038/s41419-025-07974-6