Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation

Abstract Background Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier. Apo-Tf indicates an iron-deficient environment and stimulates iron release, while holo-Tf indicates an iron sufficient...

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Bibliographic Details

Published in:	Journal of Biomedical Science
Main Authors:	Stephanie L. Baringer, Kondaiah Palsa, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor
Format:	Article
Language:	English
Published:	BMC 2023-06-01
Subjects:	Blood–brain barrier Iron Transferrin Hepcidin Ferroportin Hephaestin
Online Access:	https://doi.org/10.1186/s12929-023-00934-2