The association between altered intestinal microbiome, impaired systemic and ocular surface immunity, and impaired wound healing response after corneal alkaline-chemical injury in diabetic mice

PurposeWe aim to investigate the effect of sustained hyperglycemia on corneal epithelial wound healing, ocular surface and systemic immune response, and microbiome indices in diabetic mice compared to controls after alkaline chemical injury of the eye.MethodsCorneal alkaline injury was induced in th...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yashan Bu, Kendrick Co Shih, Ho Lam Wong, Sum Sum Kwok, Amy Cheuk-Yin Lo, Joseph Yau-Kei Chan, Alex Lap-Ki Ng, Tommy Chung-Yan Chan, Vishal Jhanji, Louis Tong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Subjects:	intestinal microbiome diabetes corneal wound healing alkaline chemical injury T-cell mediated immunity ocular surface
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1063069/full