Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer’s disease

Abstract Background The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer’s disease (EOAD). Yet, detailed examination of MTL subfields and drivers of atrophy in amnestic EOAD is lacking. Methods BioFINDER-2 participants with memory impairment, abnormal amylo...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Anika Wuestefeld, Alexa Pichet Binette, Danielle van Westen, Olof Strandberg, Erik Stomrud, Niklas Mattsson-Carlgren, Shorena Janelidze, Ruben Smith, Sebastian Palmqvist, Hannah Baumeister, David Berron, Paul A. Yushkevich, Oskar Hansson, Nicola Spotorno, Laura E.M. Wisse
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	Tau-PET imaging Amyloid-beta MRI Medial temporal lobe subregions Aging In vivo
Online Access:	https://doi.org/10.1186/s13195-024-01571-z