Clozapine Regulates Microglia and Is Effective in Chronic Experimental Autoimmune Encephalomyelitis

ObjectiveProgressive multiple sclerosis is characterized by chronic inflammation with microglial activation, oxidative stress, accumulation of iron and continuous neurodegeneration with inadequate effectiveness of medications used so far. We now investigated effects of iron on microglia and used the...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Ulaş Ceylan, Steffen Haupeltshofer, Laura Kämper, Justus Dann, Björn Ambrosius, Ralf Gold, Simon Faissner
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Subjects:	progressive multiple sclerosis neuroprotection microglia iron EAE (experimental autoimmune encephalomyelitis) clozapine
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.656941/full