Cyclophilin Inhibitor Rencofilstat Combined with Proteasome Inhibitor Ixazomib Increases Proteotoxic Cell Death in Advanced Prostate Cancer Cells with Minimal Effects on Non-Cancer Cells

<b>Background/Objective:</b> Proteotoxic stress induced by inhibitors of the ubiquitin–proteasome system has been successful in multiple myeloma but not in solid cancers such as prostate cancer. Our objective is to find a combination with proteasome inhibitors that increases apoptotic ce...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Carlos Perez-Stable, Alicia de las Pozas, Medhi Wangpaichitr, Robert T. Foster, Daren R. Ure
Format:	Article
Language:	English
Published:	MDPI AG 2025-10-01
Subjects:	cyclophilin proteasome XBP1s PERK unfolded protein response apoptosis
Online Access:	https://www.mdpi.com/2227-9059/13/10/2442