Conserved biophysical compatibility among the highly variable germline-encoded regions shapes TCR-MHC interactions

T cells are critically important components of the adaptive immune system primarily responsible for identifying and responding to pathogenic challenges. This recognition of pathogens is driven by the interaction between membrane-bound T cell receptors (TCRs) and antigenic peptides presented on major...

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Bibliographic Details

Published in:	eLife
Main Authors:	Christopher T Boughter, Martin Meier-Schellersheim
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2023-10-01
Subjects:	TCR MHC germline interactions biophysics bioinformatics co-evolution
Online Access:	https://elifesciences.org/articles/90681