Complete cross strain protection against congenital cytomegalovirus infection requires a vaccine encoding key antibody (gB) and T-cell (immediate early 1 protein) viral antigens

BackgroundCytomegalovirus is a leading cause of congenital disease, and multiple strains enable congenital CMV (cCMV) from both primary and non-primary infections. Therefore, a cross-strain protective cCMV vaccine is a high priority. Guinea pigs are the only small animal model for cCMV and guinea pi...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	K. Yeon Choi, Yushu Qin, Nadia El-Hamdi, Alistair McGregor
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	cytomegalovirus CMV congenital CMV gB IE1 CMV vaccine
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1649656/full