N-acetylcysteine: pharmacokinetic parameters and the effect on the concentration of endogenous aminothiols

We studied the pharmacokinetic parameters of N-acetylcysteine at a single oral and intravenous administration of healthy volunteers. Elimination half-life (t1/2) within 2 hours and the maximum concentration in blood (Cmax) after 1 hour after administration was more than 10 times higher when intraven...

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Bibliographic Details

Published in:	Фармакокинетика и Фармакодинамика
Main Authors:	A. A. Dutov, D. A. Nikitin, J. L. Lukianova, N. A. Shemyakina, A. V. Ermolina, M. N. Mishchenko
Format:	Article
Language:	Russian
Published:	LLC “Publisher OKI” 2016-03-01
Subjects:	n-ацетилцистеин фармакокинетика цистеин глутатион оксидативный стресс ишемический инсульт осложнения сахарного диабета n-acetylcysteine pharmacokinetics cysteine glutathione oxidative stress ischemic stroke diabetes complications
Online Access:	https://www.pharmacokinetica.ru/jour/article/view/170