Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness

Persistent cognitive impairment is a primary central nervous system-related symptom in veterans afflicted with chronic Gulf War Illness (GWI). Previous studies in a rat model have revealed that cognitive dysfunction in chronic GWI is associated with neuroinflammation, typified by astrocyte hypertrop...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N. Madhu, Dinesh Upadhya, Bing Shuai, Ashok K. Shetty
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Subjects:	cysteinyl leukotrienes gulf war illness (GWI) gulf war-related chemicals cytokines 5-lipoxygenase neuroinflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.853000/full