Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth

Malignant melanoma is a lethal skin cancer containing melanoma-initiating cells (MICs), implicated in tumorigenesis, invasion, and drug resistance, and characterized by an elevated expression of stem cell markers, including CD133. siRNA knockdown of CD133 has been previously shown to enhance apoptos...

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Bibliographic Details

Published in:	Cells
Main Authors:	Ryyan Alobaidi, Nusrat Islam, Toni Olkey, Yogameenakshi Haribabu, Mathew Shamo, Peter Sykora, Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Subjects:	NRAS drug resistance capivasertib trametinib xenograft CRISPR-Cas9
Online Access:	https://www.mdpi.com/2073-4409/14/4/248