Subcutaneous delivery of mesenchymal stromal cells induces immunoregulatory effects in the lymph node prior to their apoptosis

Abstract Background Mesenchymal stromal cell (MSC) therapy commonly involves systemic infusion of MSCs, which undergo apoptosis in the lung and induce immunoregulatory macrophages that reduce disease. The relevance of this mode of action, however, is yet to be determined for MSCs administered via ot...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Di Zheng, Tejasvini Bhuvan, Natalie L. Payne, Swee H. M. Pang, Senora Mendonca, Mark R. Hutchinson, Flyn McKinnirey, Charlotte Morgan, Graham Vesey, Laurence Meagher, Tracy S. P. Heng
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Subjects:	Mesenchymal stem cells Macrophages Inflammation Lymph nodes
Online Access:	https://doi.org/10.1186/s13287-024-04060-0