4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-<i>β</i>-Lactamases

The emergence of bacteria that co-express serine- and metallo- carbapenemases is a threat to the efficacy of the available <i>&#946;</i>-lactam antibiotic armamentarium. The 4-amino-1,2,4-triazole-3-thione scaffold has been selected as the starting chemical moiety in the design of a...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Pasquale Linciano, Eleonora Gianquinto, Martina Montanari, Lorenzo Maso, Pierangelo Bellio, Esmeralda Cebrián-Sastre, Giuseppe Celenza, Jesús Blázquez, Laura Cendron, Francesca Spyrakis, Donatella Tondi
Format:	Article
Language:	English
Published:	MDPI AG 2020-03-01
Subjects:	4-amino-1,2,4-triazole-3-thione bacterial resistance structure-based drug design non-covalent inhibition thione/thiol tautomerism broad-spectrum activity
Online Access:	https://www.mdpi.com/1424-8247/13/3/52